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Kheras, A.V., Cuchel, M., de la Llera-Moya, M., Rodrigues, A., Burke, M.F., Jafri, K., French, B.C., Phillips, J.A., Mucksavage, M.L., Wilensky, R.L., Mohler, E.R., Rothblatt, G.H. and Rader, D.J. (2011) Cholesterol efflux capacity, high density lipoprotein function and atherosclerosis. New England Journal of Medicine, 364, 127-135. http://dx.doi.org/10.1056/NEJMoa1001689
has been cited by the following article:
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TITLE:
Women with overweight, mixed hyperlipidemia, intolerance to glucose and diastolic hypertension
AUTHORS:
Ruth-Maria Korth
KEYWORDS:
Combined Telemedical Care; Overweight; Mixed Hyperlipidemia; Intolerance to Glucose; Hypertension; Renal Endothelium; Dyslipidemia; Women’s Health
JOURNAL NAME:
Health,
Vol.6 No.5,
February
27,
2014
ABSTRACT: Primarily healthy women who attended a practice of General Medicine were examined and coded data were evaluated using two statistical methods (n = 248, aged 36 ± 14 years). It was found that participants with LDL-related (mixed) hyperlipidemia showed higher blood pressure, a higher proportion of alcohol problems and/or smoking compared to normolipidemic women (p ≤ 0.05). These hyperlipidemic women who reported alcohol problems and/or smoking more often showed proteinuria and/or hematuria, rise of LDL/HDL, critical fasting blood glucose and lower HDL-cholesterol compared to hyperlipidemic women reporting healthy lifestyle (p ≤ 0.05). Likewise, high triglycerides were associated with rise of blood pressure and intolerance to glucose (p ≤ 0.05) and also with elevated total cholesterol. Alcohol-related hypertriglyceridemia overlapped with diastolic hypertension, rise of body weight and urine pathology, lowering of HDL-cholesterol and critical fasting blood glucose. The motivating message was that women with mixed hyperlipidemia and healthy lifestyle had functionally renal endothelium and healthy HDL-related baseline measures. Altogether, LDL-related hyperlipidemia and/or high triglycerides were correlated with diastolic hypertension whereby critical alcohol consumption declined renal endothelium and lowered HDL-cholesterol implicating baseline strategies to neutralize early risk factors.
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