Wandji, B.A., Bomba, F.D.T., Nkeng-Efouet, P.A., Piegang, B.N., Kamanyi, A. and Nguelefack, T.B. (2018) Antihyperalgesic Activity of the Aqueous and Methanol Extracts of the Leaves of Pittosporum mannii Hook on CFA-Induced Persistent Inflammatory Pain. Inflammopharmacology, 26, 197-205.
https://doi.org/10.1007/s10787-017-0376-6

has been cited by the following article:

• TITLE: Hepatoprotective Effects of the Leaves of Agauria salicifolia against Acetaminophen-Induced Liver Injury in Mice

  AUTHORS: Mathias K. Tsague, Lionel C. K. Bomgning, Christian K. Fofié, Elvine P. Nguelefack-Mbuyo, Agathe L. Fotio, Télesphore Benoît Nguelefack

  KEYWORDS: Agauria salicifolia, Hepatoprotection, Antioxidant, Histology

  JOURNAL NAME: Journal of Biosciences and Medicines, Vol.8 No.6, June 3, 2020

  ABSTRACT: Agauria salicifolia (Ericaceae) is a medicinal plant traditionally used for the treatment of liver ailments. The present study investigates the hepatoprotective effect of the residual aqueous fraction (RAF) of Agauria salicifolia on acetaminophen (APAP)-induced liver damage. The ethanol extract obtained as maceration of the dried leaves, was fractionated into hexane, ethyl acetate and residual aqueous fractions. Adult mice of both sexes were pre-treated with the reference drug silymarin (50 mg/kg) or RAF (100 and 200 mg/kg) during 6 days followed by a single administration of APAP (500 mg/kg) on day 7. The hepatoprotective effect and the contribution of antioxidant activities were evaluated by determining the level of transaminases in serum samples, the levels of proteins, nitric oxide (NO), malondialdehyde (MDA), glutathione (GSH), superoxide dismutase (SOD), and catalase in liver homogenates. Histological analyses of liver slides were also performed. RAF at the doses of 100 and 200 mg/kg and silymarin significantly (p increase in proteins (p p p p