TITLE:
Biocompatibility and Antibacterial Effects of 6-Deoxy-6-Aminoethyleneamino Cellulose
AUTHORS:
Susanne Finger, Michael Zieger, Cornelia Wiegand, Tim Liebert, Thomas Heinze, Peter Elsner, Uta-Christina Hipler
KEYWORDS:
6-Deoxy-6-Aminoethyleneamino Celluloses, Antibacterial, Bacteria, Biocompatibility, Biomacromolecule, Keratinocyte
JOURNAL NAME:
Journal of Biosciences and Medicines,
Vol.6 No.1,
January
10,
2018
ABSTRACT: Recently,
there is a need of alternatives to antibiotics due to increasing antibiotic-resistant
microorganism. Promising classes of bioactive polymers are 6-deoxy-6-amino
cellulose derivatives. The purpose of the study was the assessment of the
biocompatibility of 6-deoxy-6-aminoethyleneamino cellulose (AEAC) with
different degree of substitution (DS). HaCaT keratinocyte cell viability was
analyzed by measuring the cellular ATP content. The antibacterial activity
against Staphylococcus aureus and Klebsiella pneumoniae was examined by
microplate laser nephelometry. Thus, the ratio of half-maximal lethal
concentration (LC50) and half-maximal inhibitory concentration (IC50)
was calculated and described as biocompatibility index. The study revealed that
biocompatibility of AEAC depends on the DS. AEAC of low DS (0.3) showed the
best biocompatibility.