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Proceedings of the 7th National Conference on Functional Materials and Applications (FMA 2010 E-BOOK)

Changsha,China,10.16-10.18,2010

ISBN: 978-1-935068-41-9 Scientific Research Publishing, USA

E-Book 2313pp Pub. Date: October 2010

Category: Chemistry & Materials Science

Price: $360

Title: PRGD/PDLLA/n-HAP Scaffolds for Peripheral Nerve Regeneration*
Source: Proceedings of the 7th National Conference on Functional Materials and Applications (FMA 2010 E-BOOK) (pp 212-215)
Author(s): You-fa Wang, Biomedical Materials and Engineering Research Center. Wuhan University of Technology, Wuhan 430070,
Yu-hua Yan, Biomedical Materials and Engineering Research Center. Wuhan University of Technology, Wuhan 430070,
Shi-pu Li, Biomedical Materials and Engineering Research Center. Wuhan University of Technology, Wuhan 430070,
Qiong-jiao Yan, Biomedical Materials and Engineering Research Center. Wuhan University of Technology, Wuhan 430070,
Abstract: An organic/inorganic composite scaffold was designed for peripheral nerve regeneration. RGD (Arg-Gly-Asp) grafted poly{(lactic acid)–co- [(glycolic acid)-alt-(L-lysine)]} (PRGD) was synthesize to promote nerve regeneration for its inducing effect on nerve cells adhesion and guidance on directional growth of axons. Inorganic nano hydroxyapatite (n-HAP) was induced into polymer matrix to neutralize the acidity produced by the degradation products and supply Ca2+ and PO4 3- ions for axon regeneration and protein tyrosine phosphorylation. The porosity of the obtained PRGD/PDLLA/n-HAP scaffold was about 98%. Its hydrophilicity and cell affinity were improved by n-HAP. The added HAP nanoparticles can promote the RSC96 Schwann cells adhesion, proliferation and growth both on the surface of materials and inside the scaffold.
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