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Author(s): |
Bo-hua Feng, College of medical information engineering, Guangdong pharmaceutical university, Guangzhou, China
Zi-yong Zhang, College of science and engineering, Jinan University, Guangzhou, China
Xu-dong Yin, College of science and engineering, Jinan University, Guangzhou, China
Hua-xin Rao, College of science and engineering, Jinan University, Guangzhou, China
Liu-fen Peng, College of medical information engineering, Guangdong pharmaceutical university, Guangzhou, China |
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Abstract: |
A new chitosan derivate (CMC-g-RA) was prepared by grafting ricinolic acid anhydride (RA) on carboxymethy chitosan (CMC) molecules. Molecular mass, mole ratio of anhydride/amino, reaction temperature and solvent which had influence on grafting products were examined. Nanoparticles blent by botanical insecticide retenone (Rot) and CMC-g-RA as carrier was carried out. Nanoparticles were characterized by surface shape, particle size and dispersion, surface charge and loading efficiency which were influenced by CMC-g-RA and Rot concentration. The results showed that lower molecular mass was of advantage to higher degree of RA substitution. CMC-g-RA and Rot formed drug loading nanoparticles in their aqueous solution with the spherical shape and negative surface charge. The higher the concentration of Rot was, the higher the Zeta potential of Rot/CMC-g-RA nanoparticles was with narrower size dispersion. The loading efficiency of nanoparticles reached 68%.
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