TITLE:
Study of Safety of Molybdenum and Iron-Molybdenum Nanoclaster Polyoxometalates Intended for Targeted Delivery of Drugs
AUTHORS:
Alexander A. Ostroushko, Irina G. Danilova, Irina F. Gette, Svetlana Yu. Medvedeva, Margarita O. Tonkushina, Anna V. Prokofieva, Maria V. Morozova
KEYWORDS:
Buckyball, Polyoxometalates, Direct Delivery, Toxicity
JOURNAL NAME:
Journal of Biomaterials and Nanobiotechnology,
Vol.2 No.5,
December
9,
2011
ABSTRACT: Nanocluster polyoxometalates with a structure of buckyball (fullerene) are a promising means of targeted delivery of drugs in the body. In this paper, based on an analysis of histological sections of liver and kidney and peripheral blood, showed a significant reduction of toxicity of buckyballs, containing ions of molybdenum (VI), the substitution of Mo (V) ions to Fe (III), in contrast to buckyballs based on Mo (V). The absence of accumulation of molybdenum in rats with a daily intramuscular injection of aqueous solutions of both drugs within a month was confirmed.