TITLE:
An Absolute Standardized Uptake Value Is More Useful than the Decreased Rate of Uptake of FDG-PET to Predict Responses to Neoadjuvant Chemoradiotherapy for Esophageal Cancer
AUTHORS:
Masanobu Nakajima, Hiroyuki Kato, Tatsuya Miyazaki, Takanori Inose, Naritaka Tanaka, Shigemasa Suzuki, Takehiko Yokobori, Makoto Sakai, Akihiko Sano, Keisuke Ieta, Makoto Sohda, Minoru Fukuchi, Hiroyuki Kuwano
KEYWORDS:
Esophageal Cancer, Neoadjuvant Therapy, Chemoradiotherapy, FDG-PET, SUV
JOURNAL NAME:
Open Journal of Gastroenterology,
Vol.6 No.11,
November
30,
2016
ABSTRACT: Background: Neoadjuvant chemoradiotherapy (CRT) is
frequently performed for esophageal squamous cell carcinoma. In this study, we
retrospectively assessed the standardized uptake value (SUV) of FDG-PET against
decreased rates of SUV to assess the response of advanced esophageal squamous
cell carcinoma patients to neoadjuvant CRT, and the correlation of this
response with histopathological findings. Patients and Methods: Thirty-three
patients receiving CRT followed by surgery were analyzed. Results: Using the
decreased rate of maximum SUV, the sensitivity and specificity in
distinguishing complete responders (CR) from non-CR patients was 63% and 44%.
Using the maximum SUV before surgery, the sensitivity and specificity for
distinguishing pathological CR from non-CR was 88% and 56%. Conclusions: To
identify complete responders of CRT for esophageal cancer, absolute maximum SUV
value is a better predictor than decreased rate of the maximum SUV.