RETRACTED: Neutrophils in Rectal Cancer—A Review: Stage III Rectal Cancer Patients and 5-Fluorouracil Therapy. Introducing New Inclusion Criteria and Scoring System (Presenting the “Sarandria Score”)

Nicola Sarandria

University of Pavia, Pavia, Italy.

DOI: 10.4236/jct.2021.1212059                

Abstract

Short Retraction Notice

The paper has been retracted according to author’s withdrawal request. In making this decision the Editorial Board follows COPE's Retraction Guidelines. The aim is to promote the circulation of scientific research by offering an ideal research publication platform with due consideration of internationally accepted standards on publication ethics. The Editorial Board would like to extend its sincere apologies for any inconvenience this retraction may have caused.

Editor guiding this retraction: Prof. Sibu P. Saha (EiC of JCT)

The full retraction notice in PDF is preceding the original paper, which is marked "RETRACTED".

Keywords

Rectal Cancer, Neutrophils, 5-Fluorouracil, Neutrophils and Cancer, Colorec-tal Cancer

Conflicts of Interest

The authors declare no conflicts of interest.

References

[1]	Tan, S.C. (2018) Low Penetrance Genetic Polymorphisms as Potential Biomarkers for Colorectal Cancer Predisposition. The Journal of Gene Medicine, 20, e3010. https://doi.org/10.1002/jgm.3010
[2]	Yan, W.F., Wu, G., Sun, P.C. and Qiu, D. (2015) Mutations Occur More Commonly than KRAS Mutations in Colorectal Adenoma. International Journal of Clinical and Experimental Medicine, 8, 1370-1375.
[3]	Baker, S.J., Preisinger, A.C., Jessup, J.M., et al. (1990) p53 Gene Mutations Occur in Combination with 17p Allelic Deletions as Late Events in Colorectal Tumorigenesis. Cancer Research, 50, 7717-7722.
[4]	Pino, M.S. and Chung, D.C. (2010) The Chromosomal Instability Pathway in Colon Cancer. Gastroenterology, 138, 2059-2072. https://doi.org/10.1053/j.gastro.2009.12.065
[5]	Toms, J.R. (2004) CancerStats Monograph 2004. Cancer Research UK, London.
[6]	Vogelstein, B., Fearon, E.R., Hamilton, S.R., Kern, S.E., Preisinger, A.C., Leppert, M., Nakamura, Y., White, R., Smits, A.M. and Bos, J.L. (1988) Genetic Alterations during Colorectal-Tumor Development. The New England Journal of Medicine, 319, 525-532. https://doi.org/10.1056/NEJM198809013190901
[7]	Vogelstein, B., Fearon, E.R., Hamilton, S.R., Kern, S.E., Preisinger, A.C., Leppert, M., Nakamura, Y., White, R., Smits, A.M. and Bos, J.L. (1990) A Genetic Model for Colorectal Tumorigenesis.
[8]	Konishi, F. and Morson, B.C. (1982) Pathology of Colorectal Adenomas: A Colonoscopic Survey. Journal of Clinical Pathology, 35, 830-841. https://doi.org/10.1136/jcp.35.8.830
[9]	Colorectal Cancer: Statistics. Cancer.Net. https://www.cancer.net/cancer-types/colorectal-cancer/statistics#:~:text=The%205%2Dyear%20survival%20rate%20of%20people%20with%20localized%20stage,diagnosed%20at%20this%20early%20stage.&text=If%20colon%20cancer%20has%20spread,rate%20for%20people%20is%2067
[10]	Konishi, K., Fujii, T., Kato, S., et al. (1999) Clinicopathological Differences between Colonic and Rectal Carcinomas: Are They Based on the Same Mechanism of Carcinogenesis? Gut, 45, 818-821. https://doi.org/10.1136/gut.45.6.818
[11]	Baran, B., Ozupek, N.M., Tetik, N.Y., et al. (2018) Difference between Left-Sided and Right-Sided Colorectal Cancer: A Focused Review of Literature. Gastroenterology Research, 11, 264-273. https://doi.org/10.14740/gr1062w
[12]	Paschke, S., Jafarov, S., Staib, L., et al. (2018) Are Colon and Rectal Cancer Two Different Tumor Entities? A Proposal to Abandon the Term Colorectal Cancer. International Journal of Molecular Sciences, 19, Article No. 2577. https://doi.org/10.3390/ijms19092577
[13]	Hurtado, C.W. (n.d.). NASPGHAN Physiology Lecture Series: Embryology of the GI Tract: (Slides 9-12).
[14]	Balkwill, F. and Mantovani, A. (2001) Inflammation and Cancer: Back to Virchow? The Lancet, 357, 539-545. https://doi.org/10.1016/S0140-6736(00)04046-0
[15]	Pagès, F., et al. (2018) International Validation of the Consensus Immunoscore for the Classification of Colon Cancer: A Prognostic and Accuracy Study. The Lancet, 391, 2128-2139. https://doi.org/10.1016/S0140-6736(18)30789-X
[16]	Guo, G.F., et al. (2019) Immune Cell Concentrations among the Primary Tumor Microenvironment in Colorectal Cancer Patients Predicted by Clinicopathologic Characteristics and Blood Indexes. Journal for ImmunoTherapy of Cancer, 7, Article No. 179. https://doi.org/10.1186/s40425-019-0656-3
[17]	Mantovani, A., et al. (2002) Macrophage Polarization: Tumor-Associated Macrophages as a Paradigm for Polarized M2 Mononuclear Phagocytes. Trends in Immunology, 23, 549-555. https://doi.org/10.1016/S1471-4906(02)02302-5
[18]	Kather, J.N. and Halama, N. (2019) Harnessing the Innate Immune System and Local Immunological Microenvironment to Treat Colorectal Cancer. British Journal of Cancer, 120, 871-882. https://doi.org/10.1038/s41416-019-0441-6
[19]	Galdiero, M.R., et al. (2016) Occurrence and Significance of Tumor-Associated Neutrophils in Patients with Colorectal Cancer. International Journal of Cancer, 139, 446-456. https://doi.org/10.1002/ijc.30076
[20]	Mizuno, R., et al. (2019) The Role of Tumor-Associated Neutrophils in Colorectal Cancer. International Journal of Molecular Sciences, 20, Article No. 529. https://doi.org/10.3390/ijms20030529
[21]	Nozawa, H., Chiu, C. and Hanahan, D. (2006) Infiltrating Neutrophils Mediate the Initial Angiogenic Switch in a Mouse Model of Multistage Carcinogenesis. Proceedings of the National Academy of Sciences of the United States of America, 103, 12493-12498. https://doi.org/10.1073/pnas.0601807103
[22]	Hicks, A.M., Riedlinger, G., Willingham, M.C., Alexander-Miller, M.A., Von Kap-Herr, C., Pettenati, M.J., Sanders, A.M., Weir, H.M., Du, W., Kim, J., et al. (2006) Transferable Anticancer Innate Immunity in Spontaneous Regression/Complete Resistance Mice. Proceedings of the National Academy of Sciences of the United States of America, 103, 7753-7758. https://doi.org/10.1073/pnas.0602382103
[23]	Colombo, M.P., Modesti, A., Parmiani, G. and Forni, G. (1992) Local Cytokine Availability Elicits Tumor Rejection and Systemic Immunity through Granulocyte-T-Lymphocyte Cross-Talk. Cancer Research, 52, 4853-4857.
[24]	Granot, Z., Henke, E., Comen, E.A., King, T.A., Norton, L. and Benezra, R. (2011) Tumor Entrained Neutrophils Inhibit Seeding in the Premetastatic Lung. Cancer Cell, 20, 300-314. https://doi.org/10.1016/j.ccr.2011.08.012
[25]	Fridlender, Z.G., et al. (2009) Polarization of Tumor-Associated Neutrophil (TAN) Phenotype by TGF-β: “N1” versus “N2” TAN. Cancer Cell, 16, 183-194. https://doi.org/10.1016/j.ccr.2009.06.017
[26]	Berry, R.S., Xiong, M.J., Greenbaum, A., et al. (2017) High Levels of Tumor-Associated Neutrophils Are Associated with Improved Overall Survival in Patients with Stage II Colorectal Cancer. Plos ONE, 12, e0188799.
[27]	Sarandria, N. (2020) Occurrence and Clinical Significance of Tumor-Associated Neutrophils in Colorectal Cancer. Medical Graduation Thesis, Humanitas Unviersity, Pieve Emanuele.