Dr. Anamitra Ghosh

Baylor College of Medicine, Houston, TX, USA

Email: ananeuro@gmail.com

Qualifications

PhD, Iowa State University, Ames, IA, USA

MS, University of Calcutta, Kolkata, India

BS, University of Calcutta, Kolkata, India

Publications (Selected)

1. Ghosh A and Zheng H et al (2020). Epoxy fatty acid dysregulation and neuroinflammation in Alzheimer’s disease is resolved by a soluble epoxide hydrolase inhibitor. Under revision in Sci. Transl. Med.
2. Blanco FA, Czikora S, Kedei N, You Y, Pany S, Ghosh A and Das J et al (2019). Munc13 Is a Molecular Target of Bryostatin 1. Biochemistry 58 (27), 3016-3030 (Citation: 1)
3. Pany S, Ghosh A, You Y and Das J (2017). Resveratrol inhibits phorbol ester-induced membrane translocation of presynaptic Munc13–1. Biochimica et Biophysica Acta (BBA)-General Subjects. Ahead of print.
4. Sarkar S, Malovic E, Harischandra D. S, Ngwa H. A, Ghosh A, and Kanthasamy AG (2017). Manganese exposure induces neuroinflammation by impairing mitochondrial dynamics in astrocytes. NeuroToxicology. Ahead of print.
5. Langley M, Ghosh A and Kanthasamy AG (2017). Mito-Apocynin Prevents Mitochondrial Dysfunction, Microglial Activation, Oxidative Damage, and Progressive Neurodegeneration in MitoPark Transgenic Mice. Antioxidants & Redox Signaling. Ahead of print. doi:10.1089/ars.2016.6905. (Citations: 3)
6. Ghosh A and Brundin P et al (2016). Mitochondrial pyruvate carrier regulates autophagy, inflammation, and neurodegeneration in experimental models of Parkinson’s disease. Sci. Transl. Med. 8, 368ra174. (Citations: 7)
7. Gordon R, Singh N, Lawana V, Ghosh A and Kanthasamy A et al (2016). Protein kinase Cδ upregulation in microglia drives neuroinflammatory responses and dopaminergic neurodegeneration in experimental models of Parkinson's disease. Neurobiology of Disease. 93.96–114 (Citations: 17)
8. Ghosh A and Kanthasamy AG et al (2016). Mitoapocynin Treatment Protects Against Neuroinflammation and Dopaminergic Neurodegeneration in a Preclinical Animal Model of Parkinson’s Disease. J. of Neuroimm. Pharm. 10.1007/s11481-016-9650-4. (Citations: 14)
9. Harischandra DS, Jin H, Ghosh A and Kanthasamy AG (2016). Antioxidants and Redox-Based Therapeutics in Parkinson’s Disease. Inflammation, Aging, and Oxidative Stress. Springer International Publishing, 261-276
10. Jin H, Kanthasamy A, Ghosh A, and Kanthasamy AG et al (2014). Mitochondria-targeted antioxidants for treatment of Parkinson's disease: preclinical and clinical outcomes. Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease. 1842(8), 1282-1294. (Citations: 102)
11. Nordstorem U, Beauvais G, Ghosh A and Brundin P et al (2014). Progressive nigrostriatal terminal dysfunction and degeneration in the engrailed1 heterozygous mouse model of Parkinson's disease. Neurobiol Dis.73:70-82. doi: 10.1016/j.nbd.2014.09. (Citations: 25)
12. Jin H, Ghosh A and Kanthasamy AG et al (2014). Histone Hyperacetylation Up-regulates Protein Kinase Cδ in Dopaminergic Neurons to Induce Cell Death Relevance to epigenetic mechanisms of neurodegeneration in Parkinson’s disease. J. Biol Chem 289.50: 34743-34767. (Citations: 31)
13. Asaithambi A, Ay M, Jin H, Ghosh A and Kanthasamy AG et al (2014). Protein Kinase D1 (PKD1) Phosphorylation Promotes Dopaminergic Neuronal Survival during 6-OHDA-Induced Oxidative Stress. PLoS One 9.5. (Citations: 12)
14. Ghosh A and Kanthasamy AG et al (2013). The Peptidyl-prolyl Isomerase Pin1 Upregulation and Proapoptotic Function in Dopaminergic Neurons: Relevance to the Pathogenesis of Parkinson Disease. J. Biol. Chem. 10.1074/jbc.M112.444224. (Citations: 36)
15. Dranka BP, Gifford A, Ghosh A, and Kalyanaraman B. (2013). Diapocynin prevents early Parkinson's disease symptoms in the leucine-rich repeat kinase 2 (LRRK2 R1441G) transgenic mouse. Neuroscience letters, 549, 57-62. (Citations: 27)
16. Khasnavis S, Ghosh A, Roy A, Pahan K (2013). Castration induces Parkinson disease pathologies in young male mice via inducible nitric-oxide synthase. Journal of Biological Chemistry 288(29): 20843-55. (Citations: 15)
17. Ghosh A, Roy A, and Pahan K et al (2012). Sodium phenylbutyrate controls neuroinflammatory and antioxidant activities and protects dopaminergic neurons in mouse models of Parkinson’s disease. PloS one, 7(6), e38113. (Citations: 65)
18. Lin M, Chandramani P, Ghosh A and Kanthasamy A et al (2012). Methamphetamine-induced neurotoxicity linked to ubiquitin-proteasome system dysfunction and autophagy-related changes that can be modulated by protein kinase C delta in dopaminergic neuronal cells. Neuroscience 210 (2012): 308-332. (Citations: 32)
19. Wong DM, Ghosh A and Kanthasamy et al (2012). Evidence of oxidative injury of the spinal cord in 2 horses with equine degenerative myeloencephalopathy. Veterinary Pathology Online 49.6 (2012): 1049-1053. (Citations: 3)
20. Ghosh A and Kanthasamy AG et al (2012). Anti-inflammatory and neuroprotective effects of an orally active apocynin derivative in pre-clinical models of Parkinson’s disease. J Neuroinflammation 9 (1):241. (Citations: 51)
21. Jin H, Kanthasamy A, Ghosh A and Kanthasamy AG et al (2011). Alpha synuclein negatively regulates proapoptotic kinase PKC-δ expression to suppress apoptosisd in dopaminergic neurons by reducing p300 histone acetyltransferase activity. J Neuosci 31 : 2035-2051. (Citations: 79)
22. Ghosh A and Kanthasamy AG et al (2010). Neuroprotection by a mitochondria-targeted drug in a Parkinson's disease model. Free Radic Biol Med 49:1674-1684. (Citations: 85)
23. Ghosh A and Pahan K et al (2009). Simvastatin inhibits the activation of p21ras and prevents the loss of dopaminergic neurons in a mouse model of Parkinson's disease. J Neurosci 29:13543-13556. (Citations: 106)
24. Saha RN, Ghosh A and Pahan K et al (2009). TNF-alpha preconditioning protects neurons via neuron-specific up-regulation of CREB-binding protein. J Immunol 183:2068-2078. (Citations: 55)
25. Ghosh A and Pahan K et al (2007). Selective inhibition of NF-kappaB activation prevents dopaminergic neuronal loss in a mouse model of Parkinson's disease. Proc Natl Acad Sci U S A 104:18754-18759. (Citations: 258)

Personal Website:

https://scholar.google.com/citations?user=li939n0AAAAJ&hl=zh-CN&oi=ao