TITLE:
Can the Glucose Central Control System Dysfunctions Induce Diabetes Mellitus?
AUTHORS:
Altair S. de Assis, João Luiz P. da Nobrega
KEYWORDS:
Brain, Hypothalamus, CNS—Central Nervous System, Sensor Neuron Circuits, Glucose Central Control System, External Noxious Elements, Juvenile Persistent Hyperglycemia, Diabetes Mellitus, Homeostasis, Euglycemia
JOURNAL NAME:
Open Journal of Endocrine and Metabolic Diseases,
Vol.13 No.12,
December
29,
2023
ABSTRACT: We
study afresh how the glucose control system anomalies impact the organicity of
the glucose homeostasis and build up events of persistent hyperglycemia and
diabetes mellitus. We have used critically the state of art literature related
to the subject, in order to cross, to compare, and to organize the relevant
contents to create a logical and consistent support to the finds. We show that
it is consistent to assume that persistent hyperglycemia and diabetes mellitus
can have precursors not only in pancreas, but also in brain, mainly induced by
noxious dysfunctions of hypothalamus sensor neurons circuits and external
noxious elements, causing pancreas overload, and the consequent exhaustion—overburden.