Prof. Long-Sheng Chang
The Ohio State University College of Medicine, USA
Professor
Email: Long-Sheng.Chang@nationwidechildrens.org
Qualifications
1985 Postdoctoral Training, Princeton University
1984 Ph.D., Rutgers University (Formerly UMDNJ)
1978 B.Sc., National Taiwan University
Publications (Selected)
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Chow, H.Y., Dong, B., Duron, S.G., Campbell, D.A., Ong, C.C., Hoeflich,
K.P., Chang, L.-S., Welling, D.B., Yang, Z., Chernoff, J. 2015. Group I Paks as
therapeutic targets in NF2-deficient meningioma. Oncotarget 6:1981-1994. PMID:
25596744
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Petrilli, A., Copik, A., Posadas, M., Chang, L.-S., Welling, D.B.,
Giovannini, M., Fernandez-Valle, C. 2014. LIM domain kinases as a therapeutic target
for neurofibromatosis type 2. Oncogene 33:3571-3582. PMID: 23934191
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Spear, S.A., S.S. Burns, J.L. Oblinger, Y. Ren, L. Pan, A.D. Kinghorn,
D.B. Welling, L.-S. Chang. 2013. Natural compounds as potential treatments of
NF2-deficient schwannoma and meningioma: cucurbitacin D and goyazensolide.
Otol. Neurotol. 34:1519-1527. PMID: 23928514
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Burns, S.S., E.A. Akhmametyeva, J.L. Oblinger, M.L. Bush, J. Huang, V.
Senner, C.-S. Chen, A. Jacob, D.B. Welling, L.-S. Chang. 2013. AR-42, a histone
deacetylase inhibitor, differentially affects cell-cycle progression of
meningeal and meningioma cells and potently inhibits NF2‒ meningioma growth.
Cancer Res. 73:792-803. PMID: 23151902
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Wang, Y., E. Kim, X. Wang, B.G. Novitch, K. Yoshikawa, L.-S. Chang, Y.
Zhu. 2012. Neonatal MEK/ERK pathway inhibition rescues fate-specification
defects of neural progenitors and structural brain abnormalities caused by Nf1
deficiency. Cell 150:816-830. PMID: 22901811
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Jacob, A., Oblinger, J., Bush, M.L., Brendel, V., Santarelli, G., Chaudhury,
A.R., Kulp, S., La Perle, K.M., Chen, C.-S., Chang, L.-S., Welling, D.B. 2012.
Preclinical Validation of AR42, a Novel Histone Deacetylase Inhibitor, as
Treatment for Vestibular Schwannomas. Laryngoscope 122:174-189. PMID: 22109824
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Bush, M.L., J. Oblinger, V. Brendel, G. Santarelli, C. Hrelec, J. Davis,
J. Huang, E.M. Akhmametyeva, S.S. Burns, S. Kulp, C.-S. Chen, M. Giovannini,
L.-S. Chang, D.B. Welling, A. Jacob. 2011. HDAC42, A Novel Histone Deacetylase
Inhibitor, as a Potential Therapy for Vestibular Schwannomas and Meningiomas.
Neuro-Oncology 13:983-989. PMID: 21778190
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Bush, M.L., S.S. Burns, J. Oblinger, S. Davletova, L.-S. Chang, D.B.
Welling, A. Jacob. 2012. Treatment of Vestibular Schwannoma Cells with ErbB
Inhibitors. Otol. Neurotol. 33:244-257. PMID: 22222570
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Chai, G., N. Liu, J. Ma, H. Li, J.L. Oblinger, A.K. Prahalad, M. Gong,
L.-S. Chang, M. Wallace, D. Muir, A. Guha, R.J. Phipps, J.M. Hock, X. Yu. 2010.
MicroRNA-10b Regulates Tumorigenesis in Neurofibromatosis Type 1. Cancer Sci.
101:1997-2004. PMID: 20550523
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Omelyanchuk, L.V., J.A. Pertseva, S.S. Burns, and L.-S. Chang. 2009.
Evolution and Origin of HRS, a Protein Interacting with Merlin, the
Neurofibromatosis 2 Gene Product. Gene Regul. Syst. Biol. 3: 143-157. PMID:
20054405 (PMC2796970)
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Lee TX, Packer MD, Huang J, Akhmametyeva EM, Kulp S, Chen C-S, Giovannini
M, Jacob A, Welling DB, Chang L-S. 2009. Growth Inhibitory and Anti-Tumor
Activities of OSU-03012, a Novel PDK1 Inhibitor, on Vestibular Schwannoma and
Malignant Schwannoma Cells. Eur. J. Cancer 45:1709-1720. PMID: 19359162
(PMC2692816)
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Dorogova, N.V., E.M. Akhmameteva, S.A. Kopyl, N.V. Gubanova, O.S. Yudina,
L.V. Omelyanchuk, and L.-S. Chang. 2008. The Role of Drosophila Merlin in
Spermatogenesis. BMC Cell Biol. 9: 1-15. PMID: 18186933
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Jacob, A., T.X. Lee, B.A. Neff, S. Miller, D.B. Welling, and L.-S. Chang.
2008. Phosphatidylinositol 3-kinase/AKT pathway activation in human vestibular
schwannoma. Otol. Neurotol. 29:58-68. PMID: 18199958
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Chang, L.-S., A. Jacob, M. Lorenz, J. Rock, E.M. Akhmametyeva, G. Mihai,
P. Schmalbrock, A.R. Chaudhury, R. Lopez, J. Yamate, M.R. John, H. Wickert,
B.A. Neff, E. Dodson, and D.B. Welling. 2006. Growth of Benign and Malignant
Schwannoma Xenografts in Severe Combined Immunodeficiency Mice. Laryngoscope
116:2018-2026. PMID: 17075413
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Akhmametyeva, E.M., M.M. Mihaylova, H. Luo, S. Kharzai, D.B. Welling, and
L.-S. Chang. 2006. Regulation of the NF2 Gene Promoter Expression during
Embryonic Development. Dev. Dyn. 235:2771-2785. PMID: 16894610