Preparation Technology and Pharmacology of Biological Drugs
Based on modern life science, biological drugs combine advanced engineering technology and scientific principles of other basic disciplines, and transform organisms or process biological raw materials according to leading designs. Biopharmaceutical raw materials are mainly natural biological materials, including microorganisms, human body, animals, plants, Marine organisms and so on. With the development of biotechnology, purposeful artificial biological raw materials have become the main source of biopharmaceutical raw materials. Biological drugs are characterized by high pharmacological activity, small toxic and side effects and high nutritional value. Biological drugs mainly include proteins, nucleic acids, carbohydrates, lipids and so on. The constituent units of these substances are amino acids, nucleotides, monosaccharides, fatty acids, etc., which are not only harmless to the human body but also important nutrients.
Sample Chapter(s)
Informative Abstract (160 KB)
Components of the Book:
  • Head Page
  • Copyright
  • Informative Abstract
  • Content
  • Chapter 1.
    10-HDA Induces ROS-Mediated Apoptosis in A549 Human Lung Cancer Cells by Regulating the MAPK, STAT3, NF-κB, and TGF-β1 Signaling Pathways
  • Chapter 2.
    Calycosin Induces Mitochondrial-Dependent Apoptosis and Cell Cycle Arrest, and Inhibits Cell Migration through a ROS-Mediated Signaling Pathway in HepG2 Hepatocellular Carcinoma Cells
  • Chapter 3.
    Zeaxanthin Induces Apoptosis via ROS-Regulated MAPK and AKT Signaling Pathway in Human Gastric Cancer Cells
  • Chapter 4.
    2-(6-Hydroxyhexylthio)-5,8-Dimethoxy-1,4-Naphthoquinone Induces Apoptosis through ROS-Mediated MAPK, STAT3, and NF-κB Signalling Pathways in Lung Cancer A549 Cells
  • Chapter 5.
    Kaempferide Induces G0/G1 Phase Arrest and Apoptosis via ROS-Mediated Signaling Pathways in A549 Human Lung Cancer Cells
  • Chapter 6.
    Blood Urea Nitrogen May Serve as a Predictive Indicator of Retained Placenta in Dairy Cows
  • Chapter 7.
    Isoorientin Induces the Apoptosis and Cell Cycle Arrest of A549 Human Lung Cancer Cells via the ROS-Regulated MAPK, STAT3 and NF-κB Signaling Pathways
  • Chapter 8.
    Liquiritin Inhibits Proliferation and Induces Apoptosis in HepG2 Hepatocellular Carcinoma Cells via the ROS-Mediated MAPK/AKT/NF-κB Signaling Pathway
  • Chapter 9.
    Cytisine Exerts Anti-Tumour Effects on Lung Cancer Cells by Modulating Reactive Oxygen Species-Mediated Signalling Pathways
  • Chapter 10.
    2-(Naphthalene-2-Thio)-5,8-Dimethoxy-1,4-Naphthoquinone Induces Apoptosis via ROS-Mediated MAPK, AKT, and STAT3 Signaling Pathways in HepG2 Human Hepatocellular Carcinoma Cells
  • Chapter 11.
    Quinalizarin Induces Cycle Arrest and Apoptosis via Reactive Oxygen Species-Mediated Signaling Pathways in Human Melanoma A375 Cells
  • Chapter 12.
    Synthesis, Activity Evaluation, and Pro-Apoptotic Properties of Novel 1,2,4-Triazol-3-Amine Derivatives as Potent Anti-Lung Cancer Agents
  • Chapter 13.
    Quinalizarin Induces ROS-Mediated Apoptosis via the MAPK, STAT3 and NF-κB Signaling Pathways in Human Breast Cancer Cells
  • Chapter 14.
    2-(4-Methoxyphenylthio)-5,8-Dimethoxy-1,4-Naphthoquinone Induces Apoptosis via ROS-Mediated MAPK and STAT3 Signaling Pathway in Human Gastric Cancer Cells
  • Chapter 15.
    Two Novel 1,4-Naphthoquinone Derivatives Induce Human Gastric Cancer Cell Apoptosis and Cell Cycle Arrest by Regulating Reactive Oxygen Species-Mediated MAPK/AKT/STAT3 Signaling Pathways
  • Chapter 16.
    Glycitein Induces Reactive Oxygen Species-Dependent Apoptosis and G0/G1 Cell Cycle Arrest through the MAPK/STAT3/NF-κB Pathway in Human Gastric Cancer Cells
  • Chapter 17.
    New Naphthalene Derivatives Induce Human Lung Cancer A549 Cell Apoptosis via ROS-Mediated MAPKs, AKT, and STAT3 Signaling Pathways
  • Chapter 18.
    The Design of 1,4-Naphthoquinone Derivatives and Mechanisms Underlying Apoptosis Induction through ROS-Dependent MAPK/AKT/STAT3 Pathways in Human Lung Cancer Cells
  • Chapter 19.
    Mechanisms Underlying Isoliquiritigenin-Induced Apoptosis and Cell Cycle Arrest via ROS-Mediated MAPK/STAT3/NF-κB Pathways in Human Hepatocellular Carcinoma Cells
  • Chapter 20.
    Novel 1,4-Naphthoquinone Derivatives Induce Reactive Oxygen Species-Mediated Apoptosis in Liver Cancer Cells
  • Chapter 21.
    Cryptotanshinone Induces Reactive Oxygen Species-Mediated Apoptosis in Human Rheumatoid Arthritis Fibroblast-Like Synoviocytes
  • Chapter 22.
    The Compound 2-(Naphthalene-2-Thio)-5,8-Dimethoxy-1,4-Naphthoquinone Induces Apoptosis via Reactive Oxygen Species-Regulated Mitogen-Activated Protein Kinase, Protein Kinase B, and Signal Transducer and Activator of Transcription 3 Signaling in Human Gastric Cancer Cells
  • Chapter 23.
    Novel 1,4-Naphthoquinone Derivatives Induce Apoptosis via ROS-Mediated p38/MAPK, AKT and STAT3 Signaling in Human Hepatoma Hep3B Cells
  • Chapter 24.
    Quinalizarin Induces Apoptosis through Reactive Oxygen Species (ROS)-Mediated Mitogen-Activated Protein Kinase (MAPK) and Signal Transducer and Activator of Transcription 3 (STAT3) Signaling Pathways in Colorectal Cancer Cells
  • Chapter 25.
    Quinalizarin Exerts an Anti-Tumour Effect on Lung Cancer A549 Cells by Modulating the AKT, MAPK, STAT3 and p53 Signalling Pathways
  • Chapter 26.
    Cryptotanshinone Induces ROS-Mediated Apoptosis in Human Gastric Cancer Cells
  • Chapter 27.
    Ethyl 2-(Benzylidene)-7-Methyl-3-Oxo-2,3-Dihydro-5H-Thiazolo[3,2-a] Pyrimidine-6-Carboxylate Analogues as a New Scaffold for Protein Kinase Casein Kinase 2 Inhibitor
  • Chapter 28.
    Effect of Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand on the Reduction of Joint Inflammation in Experimental Rheumatoid Arthritis
  • Chapter 29.
    Biochemical, Pharmaceutical and Therapeutic Properties of Long-Acting Lithocholic Acid Derivatized Exendin-4 Analogs
  • Chapter 30.
    A New Orally Available Glucagon-Like Peptide-1 Receptor Agonist, Biotinylated Exendin-4, Displays Improved Hypoglycemic Effects in db/db Mice
  • Chapter 31.
    The Protective Effect of Chondroitin from Raja kenojei Cartilage on Collagen-Induced Arthritis in DBA/1J Mice
Readership: Students, academics, teachers and other people attending or interested in preparation technology and pharmacology of biological drugs.
1
Head Page
Cheng-Hao Jin
PDF (56 KB)
2
Copyright
Cheng-Hao Jin
PDF (111 KB)
3
Informative Abstract
Cheng-Hao Jin
PDF (160 KB)
5
Content
Cheng-Hao Jin
PDF (188 KB)
9
Chapter 1.
10-HDA Induces ROS-Mediated Apoptosis in A549 Human Lung Cancer Cells by Regulating the MAPK, STAT3, NF-κB, and TGF-β1 Signaling Pathways
Cheng-Hao Jin
PDF (38 KB)
24
Chapter 2.
Calycosin Induces Mitochondrial-Dependent Apoptosis and Cell Cycle Arrest, and Inhibits Cell Migration through a ROS-Mediated Signaling Pathway in HepG2 Hepatocellular Carcinoma Cells
Cheng-Hao Jin
PDF (27 KB)
38
Chapter 3.
Zeaxanthin Induces Apoptosis via ROS-Regulated MAPK and AKT Signaling Pathway in Human Gastric Cancer Cells
Cheng-Hao Jin
PDF (26 KB)
52
Chapter 4.
2-(6-Hydroxyhexylthio)-5,8-Dimethoxy-1,4-Naphthoquinone Induces Apoptosis through ROS-Mediated MAPK, STAT3, and NF-κB Signalling Pathways in Lung Cancer A549 Cells
Cheng-Hao Jin
PDF (38 KB)
66
Chapter 5.
Kaempferide Induces G0/G1 Phase Arrest and Apoptosis via ROS-Mediated Signaling Pathways in A549 Human Lung Cancer Cells
Cheng-Hao Jin
PDF (27 KB)
81
Chapter 6.
Blood Urea Nitrogen May Serve as a Predictive Indicator of Retained Placenta in Dairy Cows
Cheng-Hao Jin
PDF (26 KB)
90
Chapter 7.
Isoorientin Induces the Apoptosis and Cell Cycle Arrest of A549 Human Lung Cancer Cells via the ROS-Regulated MAPK, STAT3 and NF-κB Signaling Pathways
Cheng-Hao Jin
PDF (37 KB)
104
Chapter 8.
Liquiritin Inhibits Proliferation and Induces Apoptosis in HepG2 Hepatocellular Carcinoma Cells via the ROS-Mediated MAPK/AKT/NF-κB Signaling Pathway
Cheng-Hao Jin
PDF (37 KB)
118
Chapter 9.
Cytisine Exerts Anti-Tumour Effects on Lung Cancer Cells by Modulating Reactive Oxygen Species-Mediated Signalling Pathways
Cheng-Hao Jin
PDF (27 KB)
132
Chapter 10.
2-(Naphthalene-2-Thio)-5,8-Dimethoxy-1,4-Naphthoquinone Induces Apoptosis via ROS-Mediated MAPK, AKT, and STAT3 Signaling Pathways in HepG2 Human Hepatocellular Carcinoma Cells
Cheng-Hao Jin
PDF (27 KB)
144
Chapter 11.
Quinalizarin Induces Cycle Arrest and Apoptosis via Reactive Oxygen Species-Mediated Signaling Pathways in Human Melanoma A375 Cells
Cheng-Hao Jin
PDF (27 KB)
156
Chapter 12.
Synthesis, Activity Evaluation, and Pro-Apoptotic Properties of Novel 1,2,4-Triazol-3-Amine Derivatives as Potent Anti-Lung Cancer Agents
Cheng-Hao Jin
PDF (27 KB)
166
Chapter 13.
Quinalizarin Induces ROS-Mediated Apoptosis via the MAPK, STAT3 and NF-κB Signaling Pathways in Human Breast Cancer Cells
Cheng-Hao Jin
PDF (37 KB)
178
Chapter 14.
2-(4-Methoxyphenylthio)-5,8-Dimethoxy-1,4-Naphthoquinone Induces Apoptosis via ROS-Mediated MAPK and STAT3 Signaling Pathway in Human Gastric Cancer Cells
Cheng-Hao Jin
PDF (27 KB)
192
Chapter 15.
Two Novel 1,4-Naphthoquinone Derivatives Induce Human Gastric Cancer Cell Apoptosis and Cell Cycle Arrest by Regulating Reactive Oxygen Species-Mediated MAPK/AKT/STAT3 Signaling Pathways
Cheng-Hao Jin
PDF (27 KB)
206
Chapter 16.
Glycitein Induces Reactive Oxygen Species-Dependent Apoptosis and G0/G1 Cell Cycle Arrest through the MAPK/STAT3/NF-κB Pathway in Human Gastric Cancer Cells
Cheng-Hao Jin
PDF (37 KB)
220
Chapter 17.
New Naphthalene Derivatives Induce Human Lung Cancer A549 Cell Apoptosis via ROS-Mediated MAPKs, AKT, and STAT3 Signaling Pathways
Cheng-Hao Jin
PDF (27 KB)
232
Chapter 18.
The Design of 1,4-Naphthoquinone Derivatives and Mechanisms Underlying Apoptosis Induction through ROS-Dependent MAPK/AKT/STAT3 Pathways in Human Lung Cancer Cells
Cheng-Hao Jin
PDF (27 KB)
244
Chapter 19.
Mechanisms Underlying Isoliquiritigenin-Induced Apoptosis and Cell Cycle Arrest via ROS-Mediated MAPK/STAT3/NF-κB Pathways in Human Hepatocellular Carcinoma Cells
Cheng-Hao Jin
PDF (38 KB)
256
Chapter 20.
Novel 1,4-Naphthoquinone Derivatives Induce Reactive Oxygen Species-Mediated Apoptosis in Liver Cancer Cells
Cheng-Hao Jin
PDF (26 KB)
268
Chapter 21.
Cryptotanshinone Induces Reactive Oxygen Species-Mediated Apoptosis in Human Rheumatoid Arthritis Fibroblast-Like Synoviocytes
Cheng-Hao Jin
PDF (27 KB)
278
Chapter 22.
The Compound 2-(Naphthalene-2-Thio)-5,8-Dimethoxy-1,4-Naphthoquinone Induces Apoptosis via Reactive Oxygen Species-Regulated Mitogen-Activated Protein Kinase, Protein Kinase B, and Signal Transducer and Activator of Transcription 3 Signaling in Human Gastric Cancer Cells
Cheng-Hao Jin
PDF (27 KB)
292
Chapter 23.
Novel 1,4-Naphthoquinone Derivatives Induce Apoptosis via ROS-Mediated p38/MAPK, AKT and STAT3 Signaling in Human Hepatoma Hep3B Cells
Cheng-Hao Jin
PDF (27 KB)
324
Chapter 24.
Quinalizarin Induces Apoptosis through Reactive Oxygen Species (ROS)-Mediated Mitogen-Activated Protein Kinase (MAPK) and Signal Transducer and Activator of Transcription 3 (STAT3) Signaling Pathways in Colorectal Cancer Cells
Cheng-Hao Jin
PDF (27 KB)
336
Chapter 25.
Quinalizarin Exerts an Anti-Tumour Effect on Lung Cancer A549 Cells by Modulating the AKT, MAPK, STAT3 and p53 Signalling Pathways
Cheng-Hao Jin
PDF (27 KB)
346
Chapter 26.
Cryptotanshinone Induces ROS-Mediated Apoptosis in Human Gastric Cancer Cells
Cheng-Hao Jin
PDF (26 KB)
362
Chapter 27.
Ethyl 2-(Benzylidene)-7-Methyl-3-Oxo-2,3-Dihydro-5H-Thiazolo[3,2-a] Pyrimidine-6-Carboxylate Analogues as a New Scaffold for Protein Kinase Casein Kinase 2 Inhibitor
Cheng-Hao Jin
PDF (27 KB)
376
Chapter 28.
Effect of Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand on the Reduction of Joint Inflammation in Experimental Rheumatoid Arthritis
Cheng-Hao Jin
PDF (27 KB)
386
Chapter 29.
Biochemical, Pharmaceutical and Therapeutic Properties of Long-Acting Lithocholic Acid Derivatized Exendin-4 Analogs
Cheng-Hao Jin
PDF (26 KB)
396
Chapter 30.
A New Orally Available Glucagon-Like Peptide-1 Receptor Agonist, Biotinylated Exendin-4, Displays Improved Hypoglycemic Effects in db/db Mice
Cheng-Hao Jin
PDF (27 KB)
403
Chapter 31.
The Protective Effect of Chondroitin from Raja kenojei Cartilage on Collagen-Induced Arthritis in DBA/1J Mice
Cheng-Hao Jin
PDF (27 KB)
Cheng-Hao Jin (Biography)

Dong-Jie Zhang

Ying-Hua Luo

This Book

411pp. Published April 2021

Scientific Research Publishing,Inc.,USA

Category:Medicine & Healthcare

ISBN: 978-1-64997-112-8

(Paperback) USD 59.00

ISBN: 978-1-64997-113-5

(E-Book) USD 9.00

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